| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10956587 | Molecular and Cellular Neuroscience | 2012 | 13 Pages |
Abstract
NrCAM is a neuronal cell adhesion molecule of the L1 family of immunoglobulin super family. It plays a wide variety of roles in neural development, including cell proliferation and differentiation, axon growth and guidance, synapse formation, and the formation of the myelinated nerve structure. NrCAM functions in cell adhesion and modulates signaling pathways in neural development through multiple molecular interactions with guidance and other factors. Alterations in NrCAM structure/expression are associated with psychiatric disorders such as autism and drug addiction and with tumor progression. The mechanisms of NrCAM participation in development and how these might be perturbed in disorders are reviewed.
Keywords
UTRDRGRT-PCRCDRPSDSNPsPsychiatric disordersgamma amino butyric acidClinical Dementia Ratingimmunoglobulin postsynaptic densitysynapse formationCNSAxon guidanceaxon growthcentral nervous systemperipheral nervous systemVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)FibronectinCSFCerebrospinal fluidreverse transcription-PCRuntranslated regioncell adhesion moleculesElectron microscopySingle nucleotide polymorphismsCancer progressionPNSGABAdorsal root ganglia
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Authors
Takeshi Sakurai,