Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10956589 | Molecular and Cellular Neuroscience | 2012 | 12 Pages |
Abstract
During inflammation, the main differences from normal in DRG mRNA levels were bilateral, suggesting systemic regulation, although some channels showed evidence of ipsilateral modulation. By 1Â day, bilateral K2P mRNA levels had decreased (THIK1) or increased (TASK1, THIK2) but by 4Â days they were consistently decreased (TASK2, TASK3) or tended to decrease (excluding TRAAK). The decreased TASK2 mRNA was mirrored by decreased protein (TASK2-immunoreactivity) at 4Â days. Ipsilateral mRNA levels at 4Â days compared with 1Â day were lower (TRESK, TASK1, TASK3, TASK2 and THIK2) or higher (THIK1). Ipsilateral SFL duration during inflammation was positively correlated with ipsilateral TASK1 and TASK3 mRNAs, and contralateral TASK1, TRESK and TASK2 mRNAs. Thus changes in K2P mRNA levels occurred during inflammation and for 4 K2P channels were associated with spontaneous pain behaviour (SFL). K2P channels and their altered expression are therefore associated with inflammation-induced pain.
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Authors
Barnaby Marsh, Cristian Acosta, Laiche Djouhri, Sally N. Lawson,