Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10956650 | Molecular and Cellular Neuroscience | 2011 | 7 Pages |
Abstract
Our observations demonstrate that there is a rich expression of CGRP and CGRP receptor elements in the cerebellum which points towards a functional role of CGRP in cerebellar Purkinje cells. Recent advances in the biology of the cerebellum indicate that there may be a role in nociception; hence a target of the recently discovered CGRP receptor antagonists that have demonstrated improvement in migraine pain and associated symptoms could be cerebellar CGRP receptors.
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Authors
Lars Edvinsson, Sajedeh Eftekhari, Christopher A. Salvatore, Karin Warfvinge,