Differential expression of individual gamma-protocadherins during mouse brain development

Our results support the idea that Pcdhs-γ participate in neuronal differentiation and may be implicated in the fine-tuning of neuronal morphology and synaptogenesis. Cell autonomous regulation of transcription might generate the widespread distribution of individual Pcdhs-γ in the brain, which is strikingly different from the restricted expression patterns observed for classical cadherins. Thus, a defined set of Pcdhs-γ may engage in neuronal adhesion and signaling on the cellular level.