| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958064 | Neurochemistry International | 2012 | 7 Pages |
Abstract
⺠We have demonstrated that LKE is neuroprotective in a p-MCAO model of stroke. ⺠LKE's putative mechanism is in-part due to its CRMP2 mediated neurotrophic effects. ⺠LKE modulates the expression of apoptotic cascade-proteins, PARP1 and SIRT1. ⺠LKE salvaged neurons against H2O2 and t-BuOOH-mediated oxidative stress in vitro. ⺠LKE may be useful for therapeutic benefits in diseases such as stroke and ischemia.
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Authors
Shadia E. Nada, Jatin Tulsulkar, Aparna Raghavan, Kenneth Hensley, Zahoor A. Shah,