| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958082 | Neurochemistry International | 2013 | 8 Pages |
Abstract
⺠Mitochondrial dysfunction and reduced energy production occur in the aging brain. ⺠We studied if SAMP8 vs. SAMR1 mice can be used as a model for mitochondrial function. ⺠Mitochondrial function was reduced and fission enhanced in SAMP8 vs. SAMR1 mice. ⺠Curcumin-intake restored mitochondrial function & fusion, perhaps by activating PGC1α. ⺠Age-dependent changes in brain mitochondrial function can be prevented by curcumin.
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Authors
Gunter P. Eckert, Christina Schiborr, Stephanie Hagl, Reham Abdel-Kader, Walter E. Müller, Gerald Rimbach, Jan Frank,