| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958087 | Neurochemistry International | 2013 | 16 Pages |
Abstract
⺠Multiple genes have been found to be associated with Parkinson's disease. ⺠Much evidence shows that unliganded iron is also heavily involved. ⺠The gene products are involved in metabolic and signalling pathways. ⺠A systems biology approach allows one to account for these effectively. ⺠We therefore provide a unifying explanation of disease development.
Keywords
Kufor-Rakeb syndromeGBATCSInfantile neuroaxonal dystrophyMPTPNBIALRRK21-methyl-4-phenyl-1,2,3,6-tetrahydropyridineROSIronMRIneurodegeneration with brain iron accumulationLewy bodyAlzheimer’s diseaseParkinson’s diseaseMagnetic resonance imagingsubstantia nigraINADSystems biologyTranscranial sonographyGWASAmyloid plaqueleucine rich repeat kinase 2KRSglucocerebrosidaseReactive oxygen species
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Authors
Claudia Funke, Susanne A. Schneider, Daniela Berg, Douglas B. Kell,