Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats

Rotenone infusion causes OH and NO generation in 24 & 96 h in substantia nigra. ► NOS inhibitors attenuate rotenone-induced increase in brain OH, catalase and SOD. ► NOS inhibitors restore rotenone-induced loss of COX-I activity, GSH and dopamine. ► NOS inhibitors 7-NI and L-NAME possess OH radical scavenging potency.