Dopamine but not l-dopa stimulates neural glutathione metabolism. Potential implications for Parkinson's and other dopamine deficiency states

Article ID	Journal	Published Year	Pages	File Type
10958091	Neurochemistry International	2013	11 Pages	PDF

Abstract

âº Dopamine increases GSH levels in neuroblastoma cells. âº Dopamine elicits GSH release from astrocytoma cells. âº l-Dopa can elicit a similar effect in the neuronal but not astrocytic cells. âº Dopamine and GSH metabolism appear to be closely linked. âº Increasing dopamine availability may benefit GSH status.

Keywords

MAO Kelch-like ECH associating protein 1 Aromatic l-amino acid decarboxylase deficiency PKE 3-O-methyldopa MRP1 PNMT S-adenosylhomocysteine PLP tetrahydrobiopterin BH4 SAH DOPAC COMT DβH FBS GSSG SAM GSH Catechol-O-methyltransferase AADC Nrf2 3,4-dihydroxyphenylacetic acid keap1 l-3,4-dihydroxyphenylalanine l-DOPA ROS aromatic l-amino acid decarboxylase Dopamine dopamine β-hydroxylase foetal bovine serum nuclear factor erythroid 2-related factor antioxidant response elements antioxidant response element monoamine oxidase ARE homovanillic acid pyridoxal 5′-phosphate HVA reduced glutathione glutathione disulphide Reactive oxygen species