| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958096 | Neurochemistry International | 2013 | 7 Pages |
Abstract
⺠Ammonia accumulation in brain is a primary cause of hepatic encephalopathy (HE). ⺠Cytotoxic brain edema, a fatal complication of HE is due to astrocytic swelling (AS). ⺠AS in HE is a consequence of ammonia-induced oxidative nitrosative stress (AIONS). ⺠AIONS in the vascular endothelial cells contributes to vasogenic brain edema. ⺠In an antioxidative response to AIONS, astrocytes increase glutathione synthesis.
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Authors
Marta SkowroÅska, Jan Albrecht,