| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958099 | Neurochemistry International | 2013 | 7 Pages |
Abstract
⺠Respiratory complexes may not be the only major sites of ROS formation in mitochondria. ⺠E3 subunit of α-ketoglutarate dehydrogenase generates superoxide and hydrogen peroxide. ⺠Disease-causing mutations of the E3 subunit have increased ROS-generating capability. ⺠α-Glycerophosphate dehydrogenase is a unique ROS-generating site in mitochondria. ⺠ROS production by α-glycerophosphate dehydrogenase is stimulated by Ca2+ even in damaged mitochondria.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Vera Adam-Vizi, Laszlo Tretter,