Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration

Article ID	Journal	Published Year	Pages	File Type
10958101	Neurochemistry International	2013	8 Pages	PDF

Abstract

âº Oxidative stress evokes oligomerisation and secretion of synuclein (ASN). âº Secreted ASN can be transferred between neurons causing the death of the recipient cells. âº ASN evokes alterations in neurotransmission, mitochondrial dysfunction and oxidative stress. âº Secreted ASN increases the release of other amyloidogenic peptides and interact with them. âº The molecular events activated by secreted ASN lead to inflammation and selective neuronal death.

Keywords

CREB ASN TNTs nNOS ICAM-1 Aβ NAC Mmps PARP-1 NF-κB IL-6 O2−ONOO−ROS α-synuclein Hydrogen peroxide amyloid β superoxide anion Mitochondria dysfunction interleukin-6 Lewy bodies Alzheimer’s disease Neurodegenerative diseases Parkinson’s disease Oxidative stress Dopamine Hydroxyl radicals neuronal nitric oxide synthase nuclear factor kappa B Matrix metalloproteases CSF Cerebrospinal fluid intercellular adhesion molecule-1 CAN Nitric oxide H2O2 cAMP response element-binding protein Peroxynitrite Poly(ADP-ribose) polymerase-1 Calcineurin Reactive oxygen species