| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958103 | Neurochemistry International | 2013 | 7 Pages |
Abstract
⺠Thiamine deficiency (TD) models several aspects of neurodegenerative diseases (NDD). ⺠Impaired oxidative metabolism affects TD and many NDD. ⺠Oxidative stress contributes to the pathophysiology of TD in a multifactorial fashion. ⺠A variety of cellular processes are affected by oxidative stress. ⺠Understanding oxidative stress in TD may result in new treatments for NDD.
Keywords
GLASTKGDHCMAON-methyl-d-aspartateGLT-1NMDAeNOSGFAPROSAdenosine TriphosphateATPAlzheimer’s diseaseParkinson’s diseaseBBBBlood–brain barrierendothelial nitric oxide synthaseα-ketoglutarate dehydrogenase complexmonoamine oxidaseGlial fibrillary acidic proteinglutamate/aspartate transporterglutamate transporter 1Reactive oxygen species
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Authors
Alan S. Hazell, Samantha Faim, Guilherme Wertheimer, Vinicius R. Silva, Cleiton S. Marques,