Article ID Journal Published Year Pages File Type
10958110 Neurochemistry International 2013 8 Pages PDF
Abstract
► BBB penetration of verapamil during cerebral I/R injury was higher than normal. ► Up regulation of P-gp following I/R limited verapamil delivering into brain. ► Enhanced verapamil penetration following I/R mainly depended on BBB destroy. ► ICAM-1 and MMP-9 over expression induced BBB TJs destroy following I/R.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation
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