Article ID Journal Published Year Pages File Type
10958116 Neurochemistry International 2013 5 Pages PDF
Abstract
► The reduced and enhanced α3 nAChR levels in SHSY5Y cells were induced by RNAi and nicotine, respectively. ► Reducing α3 nAChR elevated BACE1, decreased BACE2 and increased β-amyloid peptide (Aβ). ► Enhancing α3 nAChR declined BACE1, elevated BACE2 and attenuated the Aβ.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
The influence of inhibiting or stimulating the expression of the α3 subunit of the nicotinic receptor in SH-SY5Y cells on levels of amyloid-β peptide and β-secretase
Authors
, , , , ,