Aldo-keto reductases mediate constitutive and inducible protection against aldehyde toxicity in human neuroblastoma SH-SY5Y cells

Article ID	Journal	Published Year	Pages	File Type
10958120	Neurochemistry International	2013	9 Pages	PDF

Abstract

âº AKR7A2 is responsible for protecting SH-SY5Y cells from methyl glyoxal toxicity. âº AKR1C3 is responsible for protecting SH-SY5Y cells from 4-hydroxynonenal toxicity. âº Expression of AKR1C and AKR1B is inducible by methyl glyoxal and 4-hydroxynonenal. âº Tert-butyl hydroquinone induces expression of AKR1B and AKR1C.

Keywords

3H-1,2-Dithiole-3-thione 4-HNE 4-hydroxynonenal AKR t-BHQ D3T tert-butylhydroquinone Small inhibitory RNA 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT RNA interference RNAi siRNA Aldehyde toxicity CSF Cerebrospinal fluid Neuroprotection Adaptive response