The role of amino acid transporters in GSH synthesis in the blood-brain barrier and central nervous system

Article ID	Journal	Published Year	Pages	File Type
10958139	Neurochemistry International	2012	10 Pages	PDF

Abstract

âº GSH is the most important antioxidant in the central nervous system (CNS). âº GSH levels are highly regulated and limited by availability of the sulfhydryl amino acid l-cys/l-cys2. âº l-cys/l-cys2 are transported by antiporter systems with different cellular distributions. âº The transport system kinetics is modulated by environmental factors.

Keywords

BEC pKa mTOR EAAC1 GCL GPX GSH PKC Nrf2 TCDD PKB PDGF LAT1 γGT APN l-Cys xCT AARE PI3K ERK 2,3,7,8-Tetrachlorodibenzo-p-dioxin membrane-associated guanylate kinase l-Glu γ-glutamyl transpeptidase γ-glutamylcysteine synthetase γ-glutamyl-cysteine amino acid Aminopeptidase N MAGUK Tight junction Oxidative stress Amino acid transporters CNS SOD Blood–brain barrier BBB brain endothelial cell Endothelial cell Superoxide dismutase Cysteine central nervous system Cystine antioxidant response element platelet-derived growth factor phosphoinositide 3-kinase Cerebrospinal fluid CSF mammalian target of rapamycin ARE protein kinase A protein kinase B Protein kinase C extracellular signal-regulated kinase Glutathione glutathione peroxidase glutamate Glycine