Article ID Journal Published Year Pages File Type
10958148 Neurochemistry International 2012 8 Pages PDF
Abstract
► Regulation of astrocytic e-5NT by TNF-α, LPS, IFN-γ, Glu and H2O2 is investigated. ► LPS, IFN-γ, Glu and H2O2 decrease, whereas TNF-α increases e-5NT activity. ► LPS, IFN-γ and Glu down-regulate e-5NT, while H2O2 modulates its enzymatic efficiancy. ► TNF-α increases e-5NT protein abundance, without alteration in mRNA expression level.
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