| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958149 | Neurochemistry International | 2012 | 8 Pages |
Abstract
⺠We obtained the κ-carrageenan oligosaccharides by enzyme degradation. ⺠The κ-carrageenan oligosaccharides were determined by HPLC, ESI-TOF-MS and 13C NMR. ⺠Activated-microglia cells can promote the development of neurodegeneration disease. ⺠The oligosaccharides can inhibit the activity of the LPS-stimulated microglia cells. ⺠We hypothesize that the effect of the oligosaccharides related to the sulfate groups.
Keywords
3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromideESI-TOF-MSLPSIL-6KOSDSKFBSIMDMIL-10MWCODMSOMTTIscove’s Modified Dulbecco’s MediumELISAEnzyme-linked immunosorbent assaytumor necrosis factor αDimethyl sulfoxide13C NMRfetal bovine serummicroglial cellelectrospray ionization time-of-flight mass spectrometryNuclear Magnetic Resonance spectrometryTNF-αlipopolysaccharideMolecular Weight Cut Offoptical densityhigh performance liquid chromatographyHPLC
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Authors
Ling Xu, Ziang Yao, Haige Wu, Feifei Wang, Shengxia Zhang,