Scaffold protein Homer 1: Implications for neurological diseases

Article ID	Journal	Published Year	Pages	File Type
10958154	Neurochemistry International	2012	8 Pages	PDF

Abstract

âº Homer 1 is the core scaffold protein of postsynaptic density. âº Effects of Homer 1a and Homer 1b/c on synaptic structure and function are different. âº The alteration of Homer 1 is involved in many neurological diseases. âº Regulation of Homer 1 is a potential treatment target for neurological diseases.

Keywords

EVH1 CaMK PLCβ VTA PKC NMDAR FMRP mGluR IP3R GKAP IEG CREB SOCS TRPC PIP2 VDCC TBI OPHN1 mRX transmembrane AMPA receptor regulatory protein Ca2+/calmodulin-dependent protein kinases Oligophrenin-1 PFC PSD AMPAR TRAP pKa NAC APP Aβ mTOR PI3K ERK1/2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor Traumatic brain injury Schizophrenia Addiction long-term depression Elk-1 Alzheimer’s disease postsynaptic density Neuropathic pain diacylglycerol DAG fragile X syndrome ubiquitin–proteasome system endoplasmic reticulum X-linked mental retardation Store-operated Ca2+ channels phosphatidylinositol bisphosphate Phosphoinositide Phospholipase Cβ phosphoinositide 3-kinase prefrontal cortex LTD ventral tegmental area mammalian target of rapamycin Nucleus accumbens voltage dependent calcium channel Pike amyloid β protein fragile X mental retardation protein amyloid precursor protein extracellular signal-regulated protein kinases 1 and 2 protein kinase A Protein kinase C Single nucleotide polymorphism SNP Immediate-early gene Transient receptor potential channel BK channels Inositol 1,4,5-trisphosphate receptor N-methyl-d-aspartate receptor Metabotropic glutamate receptor UPS