| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958156 | Neurochemistry International | 2012 | 10 Pages |
Abstract
⺠Iron accumulation is a hallmark of age related macular degeneration (AMD). ⺠Iron-induced oxidative stress triggers retinal lipid peroxidation and cell death. ⺠cPLA2 and iPLA2 activities had a differential involvement in this AMD model. ⺠cPLA2 was regulated by ERK and participates in COX-2 activation. ⺠iPLA2 had a protective effect and cPLA2 promoted retinal damage.
Keywords
iPLA2NBIAATKBELCOXcPLA24-HNE4-hydroxynonenalAMDHEPESHRPDTT3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acidBSAERK1/2MAPKMTTadenosine-5′-triphosphateATPbovine serum albuminEDTAArachidonic acidbromoenol lactonedithiothreitolage-related macular degenerationcytosolic phospholipase A2calcium-independent phospholipase A2MEKHorseradish peroxidasemitogen-activated protein kinase kinaseextracellular signal-regulated kinasesmitogen-activated protein kinases
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Authors
G. RodrÃguez Diez, R.M. Uranga, M.V. Mateos, N.M. Giusto, G.A. Salvador,