Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex

Article ID	Journal	Published Year	Pages	File Type
10958157	Neurochemistry International	2012	8 Pages	PDF

Abstract

âº Short- and long-term effects of prenatal TCDD exposure. âº Reduced cell viability and increased apoptosis in prenatally TCDD-exposed rats. âº Prenatal TCDD impairs cortical neuron development and glutamate transmission. âº Prenatal TCDD-induced alteration in glutamate signaling could underlie cognitive deficit.

Keywords

PBS Cortical slices PKC TCDD OPA AHR 2,3,7,8-Tetrachlorodibenzo-p-dioxin 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide MTT Apoptosis DIV days in vitro gestational day postnatal day Phosphate-buffered saline Protein kinase C aryl hydrocarbon receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

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Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex

Authors

Maria C. Tomasini, Sarah Beggiato, Luca Ferraro, Sergio Tanganelli, Luca Marani, Luca Lorenzini, Tiziana Antonelli,