Regulation of phosphorylation at Ser1303 of GluN2B receptor in the postsynaptic density

Article ID	Journal	Published Year	Pages	File Type
10958209	Neurochemistry International	2012	5 Pages	PDF

Abstract

âº Accessibility of phospho-GluN2B-Ser1303 in postsynaptic density (PSD) was investigated. âº Protein phosphatase 1 (PP1) in PSD dephosphorylates endogenous phospho-GluN2B-Ser1303. âº Protein kinase C (PKC) in PSD phosphorylates GluN2B-Ser1303. âº Data obtained in PSD indicates accessibility of phospho-GluN2B-Ser1303in vivo.

Keywords

NMDAR I-2 Calcium/calmodulin dependent protein kinase II PP2B PP1 CypA Cyclophilin A PKC CaMKII PP2A PSD NMDA receptor Okadaic acid CSA postsynaptic density Cyclosporin BIM Inhibitor-2 protein phosphatase 1 protein phosphatase 2A Protein phosphatase 2B Protein kinase C N-methyl-d-aspartate receptor