Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10958211 | Neurochemistry International | 2012 | 9 Pages |
Abstract
⺠SIRT2 is a class III histone deacetylse that is abundantly expressed in aging brain tissue. ⺠SIRT2 aggravates MG132-induced accumulation of ubiquitinated proteins. ⺠SIRT2 inhibits perinuclear aggresome formation and autophagic flux under proteasome inhibition.
Keywords
PEIAggresomeLC3SIRT2ECLHDACAβCMAFBSDMEM3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideChaperone-mediated autophagyBSAMTTbovine serum albuminAutophagyamyloid betaenhanced chemiluminescenceAlzheimer’s diseaseHuntington’s diseaseParkinson’s diseaseProtein accumulationNeurodegenerationRetinoic acidfetal bovine serumubiquitin–proteasome systemLAMP-2Dulbecco’s modified eagle’s mediumhistone deacetylaselysosomal-associated membrane protein 2microtubule-associated protein 1 light chain 3polyethyleneimineUPS
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Authors
Jiyeong Gal, Yeojin Bang, Hyun Jin Choi,