| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958214 | Neurochemistry International | 2012 | 10 Pages |
Abstract
⺠Staurosporine decreases AChE enzymatic activity and protein levels of tailed AChE. ⺠Staurosporine increases protein levels of readthrough AChE. ⺠Staurosporine decreases ChAT levels and activity and HACU. ⺠These effects are linked to the impact of staurosporine on phosphorylation. ⺠Initial cellular adaption is followed by neurotoxicity and cell death.
Keywords
PI3Ktetraisopropyl pyrophosphoramideMWSAnnexin V-FITCHACUAMP-PNPPP2KHBhemicholinium-3HC-3PKCPABAChE-RPBSmAbFBSPNAIso-OMPAadenosine 5′-(β,γ-imido)triphosphateMonoclonal antibodyPolyclonal antibodyAChEAcetylcholinesterasehigh affinity choline uptakeKrebs-Henseleit bufferMinimum Essential Medium Eaglestandard error of the meanRetinoic acidfetal bovine serumPhosphate buffered salinephosphoinositide 3-kinaselactate dehydrogenaseLDHMEMSEMMolecular weightProtein kinase CPropidium iodideChAToptical densitycholine acetyltransferase
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Authors
Guangfeng Li, Anne Gleinich, Helene Lau, Martina Zimmermann,