| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958226 | Neurochemistry International | 2012 | 11 Pages |
Abstract
⺠Structural models of lurasidone-GPCRs were constructed by in silico study. ⺠We elucidated structural features that gave lurasidone high receptor selectivity. ⺠We revealed structural features that differentiate lurasidone from other drugs. ⺠Structural insight was validated by the binding experiment of novel derivatives. ⺠Our protocols would realize virtual screening and SBDD for novel CNS drugs.
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Authors
Osamu Ichikawa, Kazuhiko Okazaki, Hiroyuki Nakahira, Megumi Maruyama, Ryu Nagata, Kumiko Tokuda, Tomoko Horisawa, Kazuto Yamazaki,