| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958237 | Neurochemistry International | 2012 | 12 Pages |
Abstract
⺠Nip shows protective effect against oxidative stress in RGC-5 cells. ⺠Nip induces HO-1 expression mediated by NO signaling. ⺠Nip induced NO/S-nitrosylation dependent-translocation of Nrf2 to nucleus. ⺠Nip stimulates Keap1 S-nitrosylation and Nrf2 binding to E1 enhancer. ⺠Nip prevents RGCs death and 4HNE accumulation via HO-1 induction after nerve injury.
Keywords
Heme oxygenase-1ONInipradilolS-nitrosylationKelch-like ECH-associated proteinSnMP4HNEGCLCC-PTIONQO-1NIPRGCHO-1Nrf22-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide4-hydroxy-2-nonenalkeap1Optic nerve injurychromatin immunoprecipitationOxidative stressretinal ganglion cellNF-E2-related factor 2antioxidant response elementNitric oxideARECHiPGlutamate cysteine ligase catalytic subunit
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Authors
Yoshiki Koriyama, Marie Kamiya, Tsuneo Takadera, Kunizo Arai, Kayo Sugitani, Kazuhiro Ogai, Satoru Kato,