| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958280 | Neurochemistry International | 2011 | 8 Pages |
Abstract
⺠Cultured retinal Müller cells (TR-MUL) was found to be well differentiated. ⺠TR-MUL cells expressed GS, PC and BCATm involved in glutamate metabolism. ⺠Hydrocortisone increased amidation and BCKAs increased oxidation of glutamate. ⺠Amidation and oxidation pathways of glutamate disposal did not influence each other. ⺠Glutamate uptake increased when glutamate level was decreased within Müller cells.
Keywords
Branched chain keto acidsDMEMFBSPEPCKTCAPEPDulbecco’s modified Eagle mediumBranched chain amino acidtricarboxylic acidBCAANeurodegenerationdiabetic retinopathyfetal bovine serumGlutamate excitotoxicityRetinaphosphoenol pyruvate carboxykinasephosphoenolpyruvateNeuroprotectionHydrocortisoneGlutamine synthetase
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Authors
Mohammad Shamsul Ola, Ken-Ichi Hosoya, Kathryn F. LaNoue,