Different presynaptic nicotinic receptor subtypes modulate in vivo and in vitro the release of glycine in the rat hippocampus

Article ID	Journal	Published Year	Pages	File Type
10958289	Neurochemistry International	2011	10 Pages	PDF

Abstract

âº Nicotine in vivo was able to evoke endogenous glycine release in rat hippocampus. âº Nicotinic control in vivo was mediated by different receptor subtypes. âº Nicotine elicited glycine overflow also from hippocampal synaptosomes in vitro. âº 5IA85380 and Choline were able to induce a glycine overflow from hippocampus. âº Our results indicate the existence of DHÎ²E resistant Î±4Î²2 subtypes.

Keywords

GlyRs nAChR MLA AUC DHβE In vivo release In vitro release dihydro-β-erythroidine Nicotinic receptor subtypes Synaptosomes methyllycaconitine area under the curve Hippocampus Choline Gly Glycine Nicotinic ACh receptor Glycine receptors

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

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Different presynaptic nicotinic receptor subtypes modulate in vivo and in vitro the release of glycine in the rat hippocampus

Authors

Stefania Zappettini, Elisa Mura, Massimo Grilli, Stefania Preda, Alessia Salamone, Guendalina Olivero, Stefano Govoni, Mario Marchi,