| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958293 | Neurochemistry International | 2011 | 5 Pages |
Abstract
⺠Brain ouabain is a key in blood pressure regulation upon excess sodium intake. ⺠Ouabain is produced by immortalized N1 cells, which are of hypothalamic origin. ⺠Aldosterone augments ouabain release in cultured N1 cells. ⺠Ouabain release is blocked by eplerenone, a mineralocorticoid receptor blocker. ⺠Thus, there is aldosterone-regulated secretion of ouabain by the hypothalamus.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Masamichi Yoshika, Yutaka Komiyama, Hakuo Takahashi,