Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3Î²

Article ID	Journal	Published Year	Pages	File Type
10958308	Neurochemistry International	2011	16 Pages	PDF

Abstract

âº Tau phosphorylation and neuronal apoptosis were induced by OKA, an inhibitor of PP2A. âº Lithium and 6-BIO prevented OKA-induced tau phosphorylation and neuronal apoptosis. âº Silencing of GSK3Î² by hairpin siRNA reversed tau phosphorylation and neuronal apoptosis. âº Inhibition of DYRK1A and CDK5 failed to prevent OKA-induced neuronal apoptosis. âº 6-BIBEO, a new GSK3Î² inhibitor reversed OKA-induced tau phosphorylation and apoptosis.

Keywords

NFTs PP2A catalytic subunit PP2AC OKA 6-bromoindirubin-3′-oxime GSK3β DYRK1A cdk5 PP2A Okadaic acid Alzheimer’s disease Apoptosis CNS central nervous system cyclin-dependent kinase-5 neurofibrillary tangles map Protein phosphatase-2A microtubule-associated protein Glycogen synthase kinase-3β