Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10958312 | Neurochemistry International | 2011 | 10 Pages |
Abstract
⺠SPR coupled to MS showed a putative interaction between Cav-1 and alpha-synclein. ⺠This interaction was confirmed in reciprocal magnetic pulldown experiments. ⺠Upregulation of alpha-synclein in N2A cells significantly increased levels of Cav-1. ⺠Downregulation of Cav-1 inhibited alpha-synuclein toxicity but not MG132 toxicity. ⺠Mevastatin treatment inhibited MG132 toxicity, but not alpha synuclein toxicity.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Alexandra Madeira, Junfeng Yang, Xiaoqun Zhang, Elisabet Vikeved, Anna Nilsson, Per E. Andrén, Per Svenningsson,