| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958322 | Neurochemistry International | 2011 | 14 Pages |
Abstract
⺠Dopamine heterooligomer receptor activation promotes PLC activation. ⺠PLC activation causes intracellular calcium rise and mitochondrial membrane depolarization. ⺠Mitochondrial dysfunction causes cytochrome C release and caspases 3, 7 activation and cell death. ⺠Intracellular calcium rise inhibits ERK and AKT signaling and neuronal dendrite extensions.
Keywords
DAT2-aminoethoxydiphenylborateVDAC2-APBMAOPLCMPTPIP3CREBANTERKDcfinositol 1,4,5-trisphosphateMAPKsMitogen activated protein kinasesROSSchizophreniaBongkrekic acidDopamine transporterBAPTA-AMadenine nucleotide translocaseApoptosisDendriteDopamineSODSuperoxide dismutaseendoplasmic reticulumphospholipase Cmonoamine oxidaseMACVitamin EcAMP response element binding proteinPropidium iodidevoltage-dependent anion channelCalciumextracellular-regulated kinaseReactive oxygen species
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Authors
Ling Zhang, Hui Yang, Huanying Zhao, Chunli Zhao,