| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10958337 | Neurochemistry International | 2011 | 11 Pages |
Abstract
ⶠtPA activity is transiently increased but decreased chronically in ischemic brain. ⶠtPA and PAI-1 is mainly expressed in neurons and astrocytes, respectively. ⶠtPA is released in acute condition in neurons by glutamate. ⶠPAI-1 is upregulated in chronic condition by inflammatory signal. ⶠOverall, increased PAI-1 downregulates tPA activity in chronic ischemic condition.
Keywords
CREBL-LTPDMEMJnkFBSEGR-1DTTERKHRPBDNFc-Jun N-terminal kinasesDulbecco's modified Eagle MediumcAMP response element-bindingCNSdithiothreitolfetal bovine serumcentral nervous systemBrain-derived neurotrophic factorearly growth response gene-1Horseradish peroxidaseextracellular signal-regulated kinases
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Authors
Ji Woon Kim, Sung Hoon Lee, Hyun Myung Ko, Kyoung Ja Kwon, Kyu Suk Cho, Chang Soon Choi, Jin-Hee Park, Hahn Young Kim, Jongmin Lee, Seol-Heui Han, Louis J. Ignarro, Jae Hoon Cheong, Won-Ki Kim, Chan Young Shin,