Transport of l-[14C]cystine and l-[14C]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells

It is concluded that the quantity of l-[14C]cyst(e)ine taken up by individual high affinity sodium-dependent glutamate transporters is determined both by the extracellular concentration of amino acids, such as glutamate and homocysteine, and by the extracellular redox potential, which will control the oxidation state of l-cystine.