| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10959087 | Seminars in Cell & Developmental Biology | 2012 | 5 Pages |
Abstract
⺠This review discusses recent findings on mechanisms that relate amino acids sufficiency to activation of the rapamycin-sensitive mTOR complex, mTORC1. ⺠We discuss how these mechanisms are changing our understanding of signaling control of mTOR. ⺠We highlight some general features of the amino acid-stimulated signaling pathways involved. ⺠We describe the GCN2 signaling starvation sensing mechanism induced under amino acid limitation.
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Authors
Lijun Yan, Richard F. Lamb,