PPARs: Fatty acid sensors controlling metabolism

Article ID	Journal	Published Year	Pages	File Type
10959089	Seminars in Cell & Developmental Biology	2012	9 Pages	PDF

Abstract

âº PPARs are molecular sensors of FAs and FA derivatives and control metabolism. âº The three subtypes display distinct but overlapping expression and functions. âº PPARÎ± is a major activator of FAO, e.g. in liver and BAT. âº PPARÎ´ is a major activator of oxidative metabolism and is ubiquitously expressed. âº PPARÎ³ is a major activator of adipogenesis and FA storage.

Keywords

NTD TAG TBL1 Subtype specificity GSIS TZD SREBP RXR AMPK Retinoid X receptor PPAR NF-κB DBD LBD HFD BAT AMP-activated protein kinase C/EBPα PPRE Fatty acid Post translational modifications White adipose tissue brown adipose tissue Activation function triacylglycerol thiazolidinediones N-terminal domain DNA binding domain ligand binding domain High fat diet peroxisome proliferator response element FAO nuclear factor-κB Metabolic regulation histone acetyl transferase sterol regulatory element binding protein uncoupling protein 1 WAT HAT Glucose stimulated insulin secretion Peroxisome proliferator activated receptor Nuclear receptor