| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10959095 | Seminars in Cell & Developmental Biology | 2012 | 12 Pages |
Abstract
⺠Transcription factor networks underlie primary MPC maintenance and lineage choice. ⺠Behavior of endocrine progenitors is closely tied to the 3D epithelial structure of the developing pancreas. ⺠Heightened Ngn3 expression defines endocrine commitment within the trunk epithelium. ⺠Islet subtype diversification and maturation involves specific transcription factor interactions and potential epigenetic inputs. ⺠Deeper understanding and successful mimicking of extrinsic and intrinsic interactions will improve endocrine subtype differentiation attempts in vitro.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Sebastian Rieck, Eric D. Bankaitis, Christopher V.E. Wright,