Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10959132 | Seminars in Cell & Developmental Biology | 2011 | 11 Pages |
Abstract
Kinesin motor proteins are ubiquitously involved in multiple fundamental cellular processes, coordinating transport and mediating changes to cellular architecture. Thus, specific small molecule kinesin inhibitors can shed new light on the functions of kinesins and the dynamic roles in which they participate. Here we review the range of known inhibitors, their key characteristics, and specificity, and discuss their potential suitability for chemical genetics as starting points to further investigate complex kinesin-mediated processes.
Keywords
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Authors
James A.D. Good, Dimitrios A. Skoufias, Frank Kozielski,