Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10959158 | Seminars in Cell & Developmental Biology | 2011 | 8 Pages |
Abstract
⺠Dimeric 14-3-3 isoforms modulate protein interactions in a wide range of functions. ⺠14-3-3s interact with over 200 protein kinases, phosphatases and other signalling proteins. ⺠Association usually involves phosphorylation of the interactor on novel phosphoserine motifs. ⺠Phosphorylation and other modifications of 14-3-3 itself may also modulate interaction. ⺠Acetylation of lysines or acylation of both 14-3-3 and its targets can also affect interaction.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Alastair Aitken,