14-3-3 proteins in neurodegeneration

Article ID	Journal	Published Year	Pages	File Type
10959161	Seminars in Cell & Developmental Biology	2011	9 Pages	PDF

Abstract

âº Nervous tissue specific cellular mechanisms involving 14-3-3. âº 14-3-3 isoforms integrate signalling in neuronal survival and death. âº Oxidative and endoplasmic reticulum stress. âº 14-3-3 association affects protein stability, aggregation and degradation. âº Involvement of 14-3-3 in a number of neurodegenerative diseases. âº 14-3-3 in Huntington's; Spinocerebellar ataxia; ALS; Parkinson's & Alzheimer's.

Keywords

CJD SRPK2 2D-PAGE FOX ULK1 mTORC LRRK2 TTP AP-1 BRF ASK1 NCAM NF-L SNARE DLB PGC-1α PPAR-γ DRPLA JIP-1 Jnk unc-51-like kinase 1 seven in absentia homolog GFAP LIF Variant Creutzfeldt-Jakob disease Aβ SIAH HDAC MSA SCA PP2A KSRP vCJD Hap1 AICAR 1-Methyl-4-phenyl pyridinium 3′UTR c-Jun N-terminal kinases MPP+NOx spinocerebellar ataxia Multiple system atrophy amyotrophic lateral sclerosis two-dimensional polyacrylamide gel electrophoresis Beta amyloid Creutzfeldt-Jakob disease Alzheimer disease ALS Huntington disease Neurodegenerative diseases Parkinson disease Tristetraprolin long-term potentiation LTP Dementia with Lewy bodies Neurodegeneration tyrosine hydroxylase forkhead box Neurofilament light chain three prime untranslated region leukemia inhibitory factor AU-rich element CSF Cerebrospinal fluid neural cell adhesion molecule nicotinamide adenine dinucleotide phosphate oxidase Mammalian target of rapamycin complex ARE histone deacetylase Autosomal recessive juvenile parkinsonism peroxisome proliferator-activated receptor gamma coactivator 1α 14-3-3 proteins Glial fibrillary acidic protein protein phosphatase 2A activator protein 1 huntingtin-associated protein 1 apoptosis signal-regulating kinase 1 soluble N-ethylmaleimide-sensitive factor attachment protein receptor Peroxisome proliferator-activated receptor-γ