The 14-3-3 proteins in regulation of cellular metabolism

Article ID	Journal	Published Year	Pages	File Type
10959163	Seminars in Cell & Developmental Biology	2011	7 Pages	PDF

Abstract

âº 14-3-3 Proteins are abundant and have hundreds of binding partners in eukaryotic cells. âº Many of these target phosphoproteins are involved in metabolic control. âº 14-3-3 Binding can amplify and modulate the effects of phosphorylation events. âº 14-3-3 Targets include insulin, mTOR- and AMP dependent kinase signaling pathways. âº 14-3-3 Proteins can direct metabolic activities at different cellular locations.

Keywords

AS160 GLUT CRTC 4E-BP1 Tph eIF4E-binding protein 1 ATG ULK1 GSK3 arylalkylamine N-acetyltransferase pKa mTOR GAPDH TSC1/2 FAS PRAS40 Pfk-2 unc-51-like kinase 1 ACC p70 ribosomal S6 Kinase 1 LKB1 AMPK 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase ATP synthase autophagy related Akt acetyl-CoA carboxylase fatty acid synthase Membrane association Bax BAD tyrosine hydroxylase Glucose transporter Raptor Rictor Cell signaling AANAT Metabolism BIM mammalian target of rapamycin Hydroxyindole-O-methyltransferase tryptophan hydroxylase 14-3-3 proteins Bcl-2 Associated X protein regulatory-associated protein of mTOR protein kinase B cAMP dependent protein kinase glycogen synthase kinase 3