Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10959180 | Seminars in Cell & Developmental Biology | 2011 | 9 Pages |
Abstract
Protein and DNA damage by glyoxalase system substrates is linked to dysfunction of proteins susceptible to dicarbonyl modification-the dicarbonyl proteome, and DNA instability and mutation. A component of the glyoxalase system, glyoxalase 1, is a gene with expression influential on lifespan-increasing longevity being associated with increased expression of glyoxalase 1. The glyoxalase 1 gene is also a site of copy number variation in both transcribed and non-transcribed regions giving rise to population variation of expression. The glyoxalase system and Glo1 expression particularly is therefore likely linked to healthy ageing.
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Authors
Mingzhan Xue, Naila Rabbani, Paul J. Thornalley,