| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10959221 | Seminars in Cell & Developmental Biology | 2012 | 10 Pages |
Abstract
⺠This review discusses regulatory mechanisms that contribute to the Warburg effect in cancer. ⺠We list cancers for which FDG-PET has established applications as well as those cancers for which FDG-PET has not been established. ⺠PKM2 is highlighted as an important integrator of diverse cellular stimuli to modulate metabolic flux and cancer cell proliferation. ⺠We discuss how cancer metabolism can directly influence gene expression programs. ⺠Contribution of aerobic glycolysis to the cancer microenvironment and chemotherapeutic resistance/susceptibility is also discussed.
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Authors
Steven J. Bensinger, Heather R. Christofk,