| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10959222 | Seminars in Cell & Developmental Biology | 2012 | 8 Pages |
Abstract
⺠Glutamine is consumed at high rates by many cancer and proliferating cells in order to support bioenergetics. ⺠Glutamine also contributes carbon and nitrogen to biosynthetic processes and can impact signal transduction. ⺠A growing number of oncogenes and tumor suppressors have been shown to regulate glutamine uptake and metabolism. ⺠Metabolism of glucose and glutamine, is coordinated during proliferation. ⺠New technologies for imaging glutamine metabolism may improve diagnosis and monitoring of glutaminolytic tumors.
Keywords
GlcNAcGPTGLSIDHPHDGDHMRSN-acetyl-d-glucosamineHIF-1αGSHGFATDNPSDH2-HGMYCAOAPRPPEAA2-Hydroxyglutarate6-Diazo-5-oxo-l-norleucineAminooxyacetateessential amino acidsIsocitrate dehydrogenaseGOTDONCancersuccinate dehydrogenasemagnetic resonance spectroscopyhypoxia inducible factor-1αOxidative phosphorylationfumarate hydrataseDynamic nuclear polarizationMetabolismProlyl hydroxylasepyruvate carboxylaseGlutathioneglutamate dehydrogenaseglutamineGlutaminaseGlucose
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Authors
Dania Daye, Kathryn E. Wellen,