| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10959224 | Seminars in Cell & Developmental Biology | 2012 | 8 Pages |
Abstract
⺠PGC1 family of coactivators regulate diverse metabolic functions. ⺠Cell metabolism is linked to cancer in part via PGC-1s. ⺠PGC1α promotes survival/progression by inducing cellular antioxidants/bioenergetics. ⺠Induction of anabolic metabolism by PGC-1α promotes cancer growth. ⺠Contradictory studies suggest PGC-1α inhibits tumor growth.
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Authors
Geoffrey D. Girnun,