| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10959225 | Seminars in Cell & Developmental Biology | 2012 | 6 Pages |
Abstract
⺠HIFs function in the cellular response to stress through a variety of pathways. ⺠HIF-1α and HIF-2α have opposing and overlapping roles in the microenvironment. ⺠Hypoxia and HIFs contribute to metabolic changes during tumorigenesis. ⺠The inflammatory response under hypoxia helps drive tumor progression. ⺠Hypoxia driven crosstalk influences tumor metabolism, inflammation, and malignancy.
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Authors
Jessica E.S. Shay, M. Celeste Simon,