The regulation of cancer cell death and metabolism by extracellular matrix attachment

Article ID	Journal	Published Year	Pages	File Type
10959227	Seminars in Cell & Developmental Biology	2012	10 Pages	PDF

Abstract

âº Oxidative stress can mediate the viability of ECM-detached cancer cells. âº Metabolic pathways are altered in ECM-detached cancer cells to promote survival and metastatic disease. âº Non-canonical cell death mechanisms including autophagy, entosis, and necroptosis have been shown or implicated to be involved in cell death caused by ECM-detachment. âº AMPK and HIF1 mediated signaling can modulate the survival of ECM-detached cancer cells.

Keywords

RHIM PDH TIGAR SGLT1 ANGPTL4 mTORC1 TP53-induced glycolysis and apoptosis regulator ECM ATG HIF-1α BMF MLKL PDK4 TCA PPP Rho associated protein kinase AMPK PI(3)K unc-51-like kinase 1 PYGL TNFα GLUD1 glutamate dehydrogenase 1 BDNF ROS Anoikis angiopoietin-like 4 tricarboxylic acid tumor necrosis factor alpha Cancer metabolism endoplasmic reticulum hypoxia-inducible factor 1 alpha brain derived neurotrophic factor phosphatidylinositol 3 kinase extra cellular matrix Extracellular matrix Metastasis mixed lineage kinase domain-like Cell death pentose phosphate pathway Mammalian target of rapamycin complex 1 Pleckstrin Homology Autophagy-related proteins adenosine monophosphate-activated protein kinase pyruvate dehydrogenase Pyruvate dehydrogenase kinase 4 pyruvate kinase Glul Glycogen phosphorylase Reactive oxygen species Rock