| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10959231 | Seminars in Cell & Developmental Biology | 2012 | 8 Pages |
Abstract
⺠Review models and supporting evidence for ligand endocytosis in signaling activity. ⺠Review the structural basis of the Notch autoinhibited state. ⺠Discuss a role for ligand endocytic force to expose Notch to activating proteolysis. ⺠Review findings supporting Notch conformational transformations in activation. ⺠Discuss mechanistic and functional roles of Notch conformational changes.
Keywords
NICDNotch extracellular domainNECDHeterodimerization domainNegative regulatory regionCSLAFMADAM10GSISOPNRRDllADAMEndocytosisEDTAEthylenediaminetetraacetic acidT-ALLa disintegrin and metalloproteaseNotch intracellular domainSignalingT-cell acute lymphoblastic leukemiaDelta-likeγ-secretase inhibitoratomic force microscopyNotchMechanical forcesensory organ precursor
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Authors
Abdiwahab A. Musse, Laurence Meloty-Kapella, Gerry Weinmaster,