| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10959345 | Seminars in Cell & Developmental Biology | 2008 | 8 Pages |
Abstract
Characterization of how interferons (IFNs) mediate their biological response led to identification of the JAK-STAT signaling cascade, where JAKs are receptor-associated kinases and STATs the transcription factors they activate. Today, 4 JAKs and 7 STATs are known to transduce pivotal signals for the over 50 members of the four-helix bundle family of cytokines. This review will provide an overview and historical perspective of the JAK-STAT paradigm.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Christian Schindler, Courtney Plumlee,